Been reviewing the MS documentation on 2010 in preparation for my first production 2010 deployment, and found this little titbit in this TechNet Article under ‘Enable the common language runtime’.

Use the following SQL script to improve Project Server performance, quote: “Enabling the common language runtime provides a significant improvement in performance for custom field operations.”

sp_configure ‘clr enabled’, 1
go
reconfigure
go

Simple enough, just open SQL Management Studio, connect to your SQL server and select New Query then paste and run that.